Analysis of mixed micelle formation from binary surfactants for design of potential nanosized drug carriers

Title : Analysis of mixed micelle formation from binary surfactants for design of potential nanosized drug carriers

Abstract:

The present work describes a calorimetry-founded characterization and design of a potential surfactant based colloidal drug delivery system. However, numerous research groups have published their outcomes according to the thermodynamic characterization of mixed micelle formation but only a few articles provide deeper information on the temperature and composition dependence micellization in mixed surfactant systems combining the advantages of both aspects. For self-assembled surfactant systems, the most important parameter is the critical micelle concentration (cmc) value, which quantifies the tendency to associate and gives the value of Gibbs energy of micellization. Several techniques are known for determining cmc, but the isothermal titration calorimetry (ITC) deserves special attention in comparison to other procedures. The calorimetry gives an absolute basic thermodynamic characterization in a single experiment, includes cmc and binding enthalpy and this is it does not require other label material such as fluorophore, chromophore etc. as heat is a universal signal. In contrast these advantages an important shortcoming of the procedure is that, while there are several commercial software solutions for processing calorimetric data of receptor-ligand-type interactions, the modelling of self-assembled colloidal systems must be solved by self-developed computational methods. Outcomes of the calorimetric investigation of self-assembling process were evaluated using a spreadsheet-edited routine developed for handling ITC data. Thermodynamic parameters of mixed micelle formation were obtained from the nonlinear modelling of temperature- and composition dependent enthalpograms. Further the value of thermodynamic parameters the uncertainty of these data is also very important, in this way, a weighted resampling ‘‘jackknife’’ procedure was used for calculation of the standard deviations of the fitting parameters.

Audience Take Away Notes:

• A new approach to the design of colloidal drug carriers containing surfactants
• Universal and quantitative method for the characterization of micelles formation from binary surfactants
• This research work explains the correlation of thermodynamic and functional properties of mixed surfactant systems

Biography:

Dr. Juhasz studied Chemistry at University of Szeged, Hungary and graduated as MS in 2009, then joined the research group of Prof. Imre Dékány at the Hungarian Academy of Sciences. He worked simultaneously as a researcher and managing director of a technology transfer company while received his PhD degree in 2019 at the University of Szeged. After a postdoctoral fellowship he obtained a Research fellow position of at the MTA-SZTE Lendület “Momentum” Noble Metal Nanostructures Research Group supervised by Dr. Edit Csapó. He has published more than 30 research articles and belongs the inventors of four industrial patents.